Information Request :: Site Map :: Home :: Calendars

Polybromo-1: The chromatin targeting subunit of the PBAF complex

Authors:
Thompson, M.
Published by: Biochimie
Date: 3 2009
Volume, Number, Pages: 91 3 309-319

Accession Number: 000264433400001

Abstract:

The human Polybromo-1 protein (Pb1) was recently identified as a unique subunit of the PBAF (Polybromo, Brg1-Associated Factors) chromatin-remodeling complex required for kinetochore localization during mitosis and the transcription of estrogen-responsive genes. Pb1 coordinates key features common to all remodeling complexes, including chromatin localization, recruitment of protein subunits and alteration of chromatin architecture. A comprehensive analysis of individual domains composing Pb1 is used to propose new information regarding the function of Pb1 in the PBAF chromatin-remodeling complex. The newly identified regulatory role of this important protein is also examined to explain both native function and the emerging role of Pb1 as a tumor suppressor found to be mutated in breast cancer. (C) 2008 Elsevier Masson SAS. All rights reserved.