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Targeting on Oxidative Stress: Design, Synthesis and Evaluation of New Therapeutic Agents and Diagnosis Tool for Oxidative Stress
Dr. Lanrong Bi
Assistant Professor, Department of Chemistry, Michigan Technological University
|10/19/2012 - 3:00 pm - Chemical Sciences Building, Room 101|
Reactive oxygen species (ROS) and other radicals are involved in a variety of biological phenomena, such as mutation, carcinogenesis, degenerative inflammation, aging and other diseases. ROS are well recognized for playing a dual role as deleterious and beneficial species. Recently, we have developed a series of novel fluorescent probes those can provide temporal and spatial information on reactive oxygen species in cellular system. In other words, we can “watch” the behavior of ROS in living cells in real time using fluorescent probes. In addition, we have developed new pharmaceuticals that target oxidative damage-mediated diseases. In this presentation, detailed information regarding design, synthesis and evaluation of these new therapeutic and imaging agents for oxidative stress will be discussed.