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Abstract: This presentation reviews the fundamental physical and chemical aspects of Nuclear Power from the system input as ore rock to system output electric power. The intent is to show the big picture and will include comments on my personal experiences with nuclear reactor operations and experiments. Chemistry, mathematics, and material science, are all intertwined with the physics in the six topic areas of the talk. The areas are: Ore to fuel, Flux and cross section, The fission event, Reactor theory, Reactor kinetics, and Energy conversion. There is one example calculation of critical mass from first principles. The intent is to deliver a talk which presents the vocabulary and nature of the problems in the design of nuclear power reactors.