Welcome to Fang Research group
Our research interests are in the area of organic synthesis, which include the synthesis of natural and unnatural useful molecules and development of synthetic methodologies.
Recently, we have developed a new class of chiral ligands based on two common ferrocenyl motifs. These ligands are expected to be useful in asymmetric catalysis to control the stereochemistry of a wide range of organic transformations.
Another contribution we made recently is the development of two new methods for synthetic oligonucleotide purification. Due to the use of an innovative catching by polymerization approach, these methods are suitable for large scale purification of oligonucleotide drugs.
For more information on our contributions, please see our publication list and browse around the web site.
Currently, besides continuing the above projects, we are developing new methods for creating combinatorial libraries of macrocyclic biarylether peptides, inventing new technologies for the synthesis of base-labile oligonucleotides, synthesizing DNA analogs that are useful for antisense drug applications, and discovering new organic reactions.
The most important technique students and postdocs can learn or improve in our lab is organic synthesis. Other notable ones include solid phase synthesis, automatic DNA and peptide synthesis, reverse phase and ion-exchange HPLC, polyacrylamide gel electrophoresis, NMR and GC-MS.
Shiyue Fang, PhD
Department of Chemistry
Michigan Technological University
1400 Townsend Drive
Houghton, MI 49931 USA
Office: 19-620C; Lab: 19-603
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