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2015- |
Agency : Alumni donation (MTU)
Topic : Linda J. Horton Laboratory Reasearch Fund
Principal Investigator: Ashutosh Tiwari, Ph.D.
Broad Objective: Laboratory reasearch funds for Tiwari lab.
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2015-2018 |
Agency :
National Institute of Health, NIGMS Grant
Topic : Ratiometric Near-Infrared Fluorescent Probes for Lysosomal pH in Living Cells”.
Co- Investigator: Ashutosh Tiwari, Ph.D.
Broad Objective : To synthesize and test near-infrared fluorescent probes for lysosomal pH in living cells.
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2014-2015 |
Agency :
MTU Research Excellence Fund
Topic : Understanding the role of Protein Aggregation in Cellular Toxicity.
Principal Investigator: Ashutosh Tiwari, Ph.D.
Broad Objective : The broad research objective of this proposal is to analyze a structurally diverse set of aggregation-prone proteins for their shared biochemical and biophysical properties including stability, post-translational modifications, and aggregation propensity in vitro, and to identify their interacting partners in vivo.
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2012-2013 |
Agency :
MTU Research Excellence Fund
Topic : BODIPY-based Polymeric Dyes Bearing Carbohydrate Residues for detection of Bacteria.
Co- Investigator: Ashutosh Tiwari, Ph.D.
Broad Objective : To develop a broad new class of BODIPY polymer-based ratiometric biosensors for quick, selective and sensitive detection of E. coli bacteria by using fluorescence resonance energy transfer (FRET).
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2011-2013 |
Agency :
ALS Therapy Alliance
Topic : Characterizing the surface hydrophobicity of ALS mutants of SOD1 by novel fluorescent probes.
Principal Investigator: Ashutosh Tiwari, Ph.D.
Broad Objective : To characterize abnormally exposed hydrophobic residues of SOD1 using novel fluorescent probes.
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2008-2009 |
Agency :
The Angel Fund
Topic : Altered metal binding and hydrophobic exposure of ALS mutants of Cu/Zn superoxide dismutase may be key to cellular toxicity.
Principal Investigator: Ashutosh Tiwari, Ph.D.
Broad Objective : To measure the metal (copper and zinc) affinity of purified wild type and ALS mutants of Cu/Zn superoxide dismutase (SOD1) and also define potentially toxic conformations of mutant SOD1 by mapping the exposed hydrophobic amino acids.
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2007-2008 |
Agency :
ALS Therapy Alliance
Topic : Mapping the aberrant hydrophobicity of misfolded SOD1 mutants that cause ALS
Co- Investigator: Ashutosh Tiwari, Ph.D.
Broad Objective : To map specific residues within SOD1 mutants responsible for abnormal hydrophobic exposure and binding in cellular and rodent models of ALS.
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2005-2007 |
Agency :
Amyotrophic Lateral Sclerosis Association (ALSA) and ALS Therapy Alliance
Topic : Aberrant hydrophobicity of ALS mutant Cu/Zn superoxide dismutase (SOD1) variants and its relation to toxicity
Principal Investigator: Ashutosh Tiwari, Ph.D.
Broad Objective : To map regions within SOD1 mutants responsible for abnormal hydrophobic binding and to investigate the nature of these interactions in cellular and rodent models of ALS.
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